Phase II Study of Bronchial Arterial Infusion of P53 Gene in Treatment of Multiple Lung Metastases of Hepatocellular Carcinoma
نویسندگان
چکیده
Primary hepatocellular carcinoma (HCC) is the third leading causes of cancer-related death worldwide and its five-year survival rate is under 10% [1,2]. The lungs are most common sites of metastasis of HCC and pulmonary metastatic rate of HCC is estimated around 45% [3]. After comprehensive treatment of HCC, the patients’ survival time is prolonged but companied with a high rate of late pulmonary metastasis. Thus, treatment of pulmonary metastatic tumors may offer a chance for long-term survival. Surgical removal of pulmonary metastatic tumors is an option for small fraction of patients [4]. The most HCC patients with lung pulmonary metastases are not suitable for curative pulmonary metastatic tumor resection due to patients’ poor condition or multiple metastases.
منابع مشابه
p53 gene therapy for pulmonary metastasis tumor from hepatocellular carcinoma.
The objective of this study is to explore the safety, efficacy, and administration method of the recombinant adenovirus p53 gene (rAd-p53, or gendicine) in the treatment of pulmonary metastasis tumor from advanced hepatocellular carcinoma (HCC). Pulmonary metastasis tumors from HCC in 20 patients were treated by using transcatheter bronchial arterial gendicine infusion combined with transcathet...
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